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Monday, April 2, 2012

Acute pyelonephritis Histology and Explanation

Acute pyelonephritis is an exudative purulent localized inflammation of kidney and renal pelvis. The renal parenchyma presents in the interstitium abscesses (suppurative necrosis), consisting in purulent exudate (pus): neutrophils, fibrin, cell debris and central germ colonies (hematoxylinophils). Tubules are damaged by exudate and may contain neutrophil casts. In the early stages, glomeruli and vessels are normal.



This is an ascending bacterial infection leading to acutepyelonephritis. Numerous PMN's are seen filling renal tubules across thecenter and right of this picture.

At high magnification, many neutrophils are seen in the tubules andinterstitium in a case of acute pyelonephritis

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